Endocrine Abstracts

While it is well established that vascular endothelial growth factor-A (VEGF) is an indispensable mediator of normal and pathological angiogenesis, other molecules in the local microenvironment play important roles in modulating the proangiogenic effects of VEGF. For example, Notch receptors are expressed in the vasculature and genetic deletion of Notch1 or key downstream signaling elements results in embryonic lethality associated with vascular remodeling defects. Although mo...